Metabolomic tests measure small molecules in the body for personalized medical interventions that correct deficiencies and metabolic dysfunctions. Metabolomic Analysis®
The Key to Successfully Treating Autoimmune and Chronic Diseases Lies in the Ability to Measure Very Small Molecules Accurately.
Metabolomic analysis can aid in the prevention and treatment of autoimmune and chronic diseases such as Hashimoto's thyroiditis, diabetes, insulin resistance, metabolic syndrome, rheumatoid arthritis, psoriasis, lupus, and multiple sclerosis.
Metabolomic analysis is a highly sensitive testing method that captures metabolic dysfunctions arising from a disease or causing its onset (1).
Small molecules in the body are measured to identify underlying causes of autoimmune and chronic diseases.
This analysis method is highly accurate in detecting micronutrient deficiencies and metabolic disorders. It can identify disorders like insulin resistance, microbiome imbalance, and disruptions that cause chronic inflammation in individuals and provide a precise picture of their health.
This method enables effective prevention and treatment of chronic diseases (1-6).
Metabolomic analysis is a powerful tool that can detect disruptions in the body's function at a molecular level long before the onset of a disease. Such analysis provides critical information that can be used to determine appropriate and targeted medical interventions, including medication, lifestyle modifications, and dietary adjustments. In the vast majority of cases, these interventions can lead to significant long-term improvements in health (1,5,7-12).
Markers Detected through Metabolomic Analysis®
Metabolomic Analyses detect markers that identify:
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Deficiencies in vitamins, enzymes, minerals, amino acids, and omega-3 fatty acids
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Insulin resistance and its causing factors
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The ability of the body to manage inflammation
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Energy production efficiency (mitochondrial function)
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The body's antioxidant capacity
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The gut flora state (microbiome)
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Proteins, carbohydrates, and lipids disorders metabolism
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Neurotransmitter metabolism: serotonin, dopamine, adrenaline and GABA
- Hormone function disorders
In recent years, advances in metabolomic analysis have made it possible to measure small molecules involved in the body's chemical reactions, which enables the accurate detection of metabolic disorders and deficiencies (1).
This additional diagnostic tool helps correct deficiencies by using therapeutic doses of micronutrients. Restoring healthy metabolic function can enhance patients' overall health and improve the course of chronic illnesses, such as autoimmune, cardiovascular, diabetes, and respiratory system diseases (1,5,7-11).
How the Tests Are Performed
Metabolomic Analysis is performed on blood and urine samples in one of the 20 accredited global laboratories for metabolic diseases, meeting the highest technical standards.
The metabolomic analysis laboratory is certified by:
- The European Research and Diagnosis Organization for Inherited and Metabolic Diseases, ERNDIM: the scientific organization with the highest laboratory standards worldwide.
- The Centers for Disease Control (CDC) of the USA.
- The US National Institute of Standards and Technology (NIST).
- The medical laboratory has been certified under the ISO 17025 / 15189 standards.
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Image: International Organizations for Quality Certification of Metabolomic Analyses
Metabolomic Tests are Critical in Effectively Treating Autoimmune & Chronic Diseases
Metabolomic tests are used to tailor therapeutic plans based on individual metabolic profiles for specific disease categories (1-5, 9-13):
- Autoimmune diseases
- Chronic Diseases (diseases lasting more than three months)
- Thyroid diseases (Hashimoto's, hypothyroidism, hyperthyroidism)
- Cardiovascular diseases
- Diabetes
- Metabolic syndrome
- Gastrointestinal diseases
- Chronic fatigue
- Obesity
- Hormone problems
- Prevention
Based on our clinical experience with more than 25.000 patients, targeted correction of deficiencies and restoration of metabolic risk factors contribute to:
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Improvement of disease symptoms
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Address chronic inflammation
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Curbing the progression of the disease
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Enhance the overall health and well-being of patients
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Increasing energy levels
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Improving quality of life
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Improve response to medication, lessening side effects and enhancing symptom control
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Improve mental clarity and concentration
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Improve mood swings
- Improve gastrointestinal function
The advantage of metabolomics is that it combines an individual's genetic variability with their personal dietary and lifestyle choices to shape their current health.
Today, the field of medicine has more advanced tools than it did just five or ten years ago. In many cases, specific medical interventions that target lifestyle, dietary modifications, and deficiencies in the body can bring about significant and long-lasting improvements in overall health.
When treating deficiencies, and each patient's diet and pharmaceutical treatment are customized to match their unique metabolic profile, this individualized approach can drastically change the trajectory of chronic and autoimmune diseases, leading to improved health outcomes and a better quality of life.
Sample Reports
Metabolomic Analysis Organic Acids
Metabolomic Analysis Fatty Acids
Metabolomic Analysis Sample Report
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Bibliographic References
- Micronutrient deficiencies in patients with COVID-19: how metabolomics can contribute to their prevention and replenishment. Dimitris Tsoukalas and Evangelia Sarandi. BMJ Nutri Prev Heal. Nov. 2020; bmjnph-2020-000169
- The Fingerprints of Diabetes…and Other Diseases. Harvard Magazine
- Metabolic profiling of organic and fatty acids in chronic and autoimmune diseases. Evangelia Sarandi, Dimitris Tsoukalas et al. Advances in Clinical Chemistry. July 15, 2020. Elsevier Inc.
- Metabonomic fingerprints of fasting plasma and spot urine reveal human pre-diabetic metabolic traits Xinjie Zhao et al. Metabolomics. 2010.
- Fathoming Metabolism. Harvard Magazine.
- Höller U, Bakker SJL, Düsterloh A, et al. Micronutrient status assessment in humans: current methods of analysis and future trends. TrAC Trends in Analytical Chemistry 2018
- Metabolomics: From Fundamentals to Clinical Applications. A. Sussulini. Springer International Publishing AG 2017 (ed.).
- Sharpening Precision Medicine by a Thorough Interrogation of Metabolic Individuality. K. Beebe, A.D. Kennedy. Computational and Structural Biotechnology Journal, 2016.
- Urinary organic acids as biomarkers in the assessment of pulmonary function in children with asthma Papamichael M.M., Katsardis C, Erbas B, Itsiopoulos C, Tsoukalas D. Nutrition Research 2018. https://www.sciencedirect.com/science/article/pii/S027153171830335X
- Application of metabolomics: Focus on the quantification of organic acids in healthy adults. Tsoukalas D et al. IJMM 2017 https://www.spandidos-publications.com/ijmm/40/1/112
- Application of metabolomics part II: Focus on fatty acids and their metabolites in healthy adults Tsoukalas D. et al. IJMM 2019. https://www.spandidos-publications.com/ijmm/43/1/233
- Targeted Metabolomic Analysis of Serum Fatty Acids for the Prediction of Autoimmune Diseases Dimitris Tsoukalas1,2,3, Vassileios Fragoulakis4, Evangelia Sarandi2,5, Anca Oana Docea6, Evangelos Papakonstaninou2, Gerasimos Tsilimidos2, Chrysanthi Anamaterou2, Persefoni Fragkiadaki5, Michael Aschner7, Aristidis Tsatsakis3,5, Nikolaos Drakoulis8 and Daniela Calina1. Front. Mol. Biosci., 01 November 2019 | https://doi.org/10.3389/fmolb.2019.00120
- Metabolomics Oncology
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