Metabolomic analyses are a sensitive measurement method applied to autoimmune and chronic diseases.Metabolomic Testing Shapes the Management of Autoimmune and Chronic Diseases
Blood analysis of small molecules detects metabolic disorders associated with the course and onset of autoimmune and chronic diseases. An individual's metabolic state is the leading risk factor for the onset of these types of diseases(1-5).
Metabolomic analyses are a sensitive measurement method that captures metabolic dysfunctions arising from a disease or cause its onset. They provide an accurate picture of each individual's health status.
They detect deficiencies in micronutrients and metabolic disorders and determine targeted medical interventions in medication, lifestyle, micronutrient deficiencies, and diet. These interventions bring long-term and significant improvement in the majority of cases (68-98% of cases, varying with the condition).
Addressing deficiencies and managing metabolic risk factors effectively leads to:
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Improved effectiveness of medical treatments
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Alleviation of disease-related symptoms
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Slowing down or stopping the progression of the illness
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Enhanced overall quality of life
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Strengthening of the body's health
- Boosted energy levels
Furthermore, in terms of prevention, early identification of risk factors enables prompt preventive measures to lower the likelihood of developing a disease(1,5,7-12).
Metabolomic Testing Shapes the Management of Autoimmune and Chronic Diseases
The metabolomic analysis is crucial in tailoring therapeutic strategies, focusing on the distinctive metabolic profile of each patient. These tests are relevant for a range of diseases(1-5, 9-13), including:
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Autoimmune conditions
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Chronic diseases (lasting more than three months)
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Thyroid disorders
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Digestive system diseases
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Cardiovascular diseases
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Diabetes
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Metabolic syndrome
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Neurological conditions (such as Multiple Sclerosis and Alzheimer's disease)
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Persistent fatigue
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Obesity
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Hormonal disorders
- Disease prevention
The strength of metabolomic analyses lies in integrating a person's genetic variation with their individual dietary and lifestyle choices, thereby reflecting their present health condition.
Today, medicine has more resources than a decade or even five years ago. Personalized interventions focusing on lifestyle, nutrition, and correcting micronutrient deficiencies can lead to substantial, lasting improvements in most cases.
Customizing each patient's pharmaceutical treatment, supplementation regimen, and diet to their unique metabolic profile can profoundly change the course of autoimmune and chronic diseases.
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Bibliographic References
- Micronutrient deficiencies in patients with COVID-19: how metabolomics can contribute to their prevention and replenishment. Dimitris Tsoukalas and Evangelia Sarandi. BMJ Nutri Prev Heal. Nov. 2020; bmjnph-2020-000169
- The Fingerprints of Diabetes…and Other Diseases. Harvard Magazine
- Metabolic profiling of organic and fatty acids in chronic and autoimmune diseases. Evangelia Sarandi, Dimitris Tsoukalas et al. Advances in Clinical Chemistry. July 15, 2020. Elsevier Inc.
- Metabonomic fingerprints of fasting plasma and spot urine reveal human pre-diabetic metabolic traits Xinjie Zhao et al. Metabolomics. 2010.
- Fathoming Metabolism. Harvard Magazine.
- Höller U, Bakker SJL, Düsterloh A, et al. Micronutrient status assessment in humans: current methods of analysis and future trends. TrAC Trends in Analytical Chemistry 2018
- Metabolomics: From Fundamentals to Clinical Applications. A. Sussulini. Springer International Publishing AG 2017 (ed.).
- Sharpening Precision Medicine by a Thorough Interrogation of Metabolic Individuality. K. Beebe, A.D. Kennedy. Computational and Structural Biotechnology Journal, 2016.
- Urinary organic acids as biomarkers in the assessment of pulmonary function in children with asthma Papamichael M.M., Katsardis C, Erbas B, Itsiopoulos C, Tsoukalas D. Nutrition Research 2018. https://www.sciencedirect.com/science/article/pii/S027153171830335X
- Application of metabolomics: Focus on the quantification of organic acids in healthy adults. Tsoukalas D et al. IJMM 2017 https://www.spandidos-publications.com/ijmm/40/1/112
- Application of metabolomics part II: Focus on fatty acids and their metabolites in healthy adults Tsoukalas D. et al. IJMM 2019. https://www.spandidos-publications.com/ijmm/43/1/233
- Targeted Metabolomic Analysis of Serum Fatty Acids for the Prediction of Autoimmune Diseases Dimitris Tsoukalas1,2,3, Vassileios Fragoulakis4, Evangelia Sarandi2,5, Anca Oana Docea6, Evangelos Papakonstaninou2, Gerasimos Tsilimidos2, Chrysanthi Anamaterou2, Persefoni Fragkiadaki5, Michael Aschner7, Aristidis Tsatsakis3,5, Nikolaos Drakoulis8 and Daniela Calina1. Front. Mol. Biosci., 01 November 2019 | https://doi.org/10.3389/fmolb.2019.00120
- Metabolomics Oncology
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