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Many individuals with Hashimoto's thyroiditis continue to experience debilitating symptoms, despite having normal blood tests.
Understanding the Discrepancy Between Normal Blood Tests and Persistent Symptoms in Hashimoto's Thyroiditis
Despite thyroid function tests indicating normal results, many individuals with Hashimoto's thyroiditis continue to experience debilitating symptoms.
The cause of these ongoing symptoms often lies in hard-to-detect micronutrient deficiencies and metabolic dysfunctions.
The Hidden Culprits: Micronutrient Deficiencies and Metabolic Dysfunctions
Patients with Hashimoto's disease frequently suffer from energy depletion, unexplained weight gain, mood swings, intestinal issues, cognitive impairments, and muscle or joint pain[1-3].
These symptoms stem from deficiencies in essential vitamins, minerals, antioxidants and metabolic issues like insulin resistance and microbiome dysbiosis[4-8].
Unfortunately, these underlying problems often evade detection through standard thyroid function tests.
Why Standard Testing Falls Short
Standard thyroid tests, while crucial, only provide a partial picture of thyroid health. They fail to identify the nuanced metabolic disorders and marginal micronutrient deficiencies that significantly impact patients' quality of life[8,9].
This gap in diagnostic capability leads to a situation where patients' symptoms persist despite their thyroid hormone levels appearing normal.
The Game-Changer: Metabolomic Analysis
Metabolomic analysis is a groundbreaking approach to detecting these elusive deficiencies and dysfunctions. Unlike conventional tests, this method delves deep into the body's metabolic processes, uncovering issues like insulin resistance, inflammation, and deficiencies in critical nutrients[8-13].
By addressing these hidden factors, patients experience marked improvements in energy, weight management, inflammation, mood, mental clarity, and overall disease course.
Beyond Hormone Regulation: A Comprehensive Treatment Approach
Hashimoto's thyroiditis, a common autoimmune condition, demands a treatment approach that transcends mere hormone regulation.
Identifying and correcting the accompanying micronutrient deficiencies and metabolic disorders is essential. Without addressing these factors, patients may face a gradual deterioration in their health.
The Power of Metabolomic-Guided Treatment
The implementation of metabolomic-guided treatment in Hashimoto's disease has shown promising results. It not only protects the thyroid gland from further damage but also enhances the functioning of the remaining gland, balances metabolism, and reduces the risk of other autoimmune conditions.
This comprehensive approach typically requires a sustained effort over months but leads to a significant and lasting improvement in patients' lives.
Within the last fifteen years, our clinic has performed more than 50.000 metabolomic analyses. More than 85% of our Hashimoto disease patients improve their health.
It usually takes 6-8 months to achieve significant change, a year to stabilize the body at a better functional level, and about two years for optimal results.
For those struggling with Hashimoto's thyroiditis, it's crucial to recognize the importance of looking beyond standard thyroid tests.
The metabolomic analysis offers a more comprehensive understanding of the disease, leading to targeted treatments addressing micronutrient deficiencies and metabolic dysfunctions that aggravate persistent symptoms.
By identifying and correcting deficiencies and metabolic disruptions, patients can significantly improve their quality of life and change the course of their disease towards steady improvement.
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Bibliographic References
[1] Is a Normal TSH Synonymous With “Euthyroidism”?
Sarah J. Peterson, Elizabeth A. McAninch, Antonio C. Bianco. The Journal of Clinical Endocrinology & Metabolism 2016.
Sarah J. Peterson, Elizabeth A. McAninch, Antonio C. Bianco. The Journal of Clinical Endocrinology & Metabolism 2016.
[2] Persisting symptoms in patients with Hashimoto’s disease despite normal thyroid hormone levels: Does thyroid autoimmunity play a role? A systematic review. Karelina L. Groenewegen et al. J Transl Autoimmun. 2021.
[3] Cognitive and Affective Dysfunctions in Autoimmune Thyroiditis Thomas Leyhe, Karsten Müssig. Brain Behav Immun . 2014
[4] Multiple Nutritional Factors and the Risk of Hashimoto's Thyroiditis Shiqian Hu, Margaret P Rayman. Thyroid . 2017 May. https://pubmed.ncbi.nlm.nih.gov/28290237/
[5] Correlation Between Hashimoto's Thyroiditis-Related Thyroid Hormone Levels and 25-Hydroxyvitamin D Guanqun Chao, Yue Zhu, Lizheng Fang. Front Endocrinol (Lausanne). 2020 Feb. https://pubmed.ncbi.nlm.nih.gov/32117049/
[6] Changes in Glucose-Lipid Metabolism, Insulin Resistance, and Inflammatory Factors in Patients With Autoimmune Thyroid Disease Yi Lei et. al. J Clin Lab Anal . 2019https://pubmed.ncbi.nlm.nih.gov/31350776/
[7] Metabolic Characteristics of Hashimoto's Thyroiditis Patients and the Role of Microelements and Diet in the Disease Management-An Overview. Aniceta A Mikulska et al. Int J Mol Sci . 2022 https://pubmed.ncbi.nlm.nih.gov/35743024/
[8] Targeted Metabolomic Analysis of Serum Fatty Acids for the Prediction of Autoimmune Diseases. Dimitris Tsoukalas, Vassileios Fragoulakis, Evangelia Sarandi et. al. Frontiers in Molecular Biosciences, Metabolomics (6), 2019, Published 1 November 2019.[9] Micronutrient deficiencies in patients with COVID-19: how metabolomics can contribute to their prevention and replenishment. Dimitris Tsoukalas and Evangelia Sarandi. BMJ Nutri Prev Heal. Nov. 2020; bmjnph-2020-000169
[10] Prediction of Autoimmune Diseases by Targeted Metabolomic Assay of Urinary Organic Acids. Dimitris Tsoukalas et. al. Metabolites. 2020 Dec 8.
[11] Metabolic profiling of organic and fatty acids in chronic and autoimmune diseases. Evangelia Sarandi, Dimitris Tsoukalas et al. Advances in Clinical Chemistry. July 15, 2020. Elsevier Inc.
[12] A Clinical Trial for the Identification of Metabolic Biomarkers in Hashimoto’s Thyroiditis and in Psoriasis: Study Protocol by Evangelia Sarandi et al Pathophysiology 2021 https://www.mdpi.com/1873-149X/28/2/19
[13] Non-communicable Diseases in the Era of Precision Medicine: An Overview of the Causing Factors and Prospects. Dimitris Tsoukalas et al. Bio#Futures. Springer, Cham. May 2021.
[3] Cognitive and Affective Dysfunctions in Autoimmune Thyroiditis Thomas Leyhe, Karsten Müssig. Brain Behav Immun . 2014
[4] Multiple Nutritional Factors and the Risk of Hashimoto's Thyroiditis Shiqian Hu, Margaret P Rayman. Thyroid . 2017 May. https://pubmed.ncbi.nlm.nih.gov/28290237/
[5] Correlation Between Hashimoto's Thyroiditis-Related Thyroid Hormone Levels and 25-Hydroxyvitamin D Guanqun Chao, Yue Zhu, Lizheng Fang. Front Endocrinol (Lausanne). 2020 Feb. https://pubmed.ncbi.nlm.nih.gov/32117049/
[6] Changes in Glucose-Lipid Metabolism, Insulin Resistance, and Inflammatory Factors in Patients With Autoimmune Thyroid Disease Yi Lei et. al. J Clin Lab Anal . 2019https://pubmed.ncbi.nlm.nih.gov/31350776/
[7] Metabolic Characteristics of Hashimoto's Thyroiditis Patients and the Role of Microelements and Diet in the Disease Management-An Overview. Aniceta A Mikulska et al. Int J Mol Sci . 2022 https://pubmed.ncbi.nlm.nih.gov/35743024/
[8] Targeted Metabolomic Analysis of Serum Fatty Acids for the Prediction of Autoimmune Diseases. Dimitris Tsoukalas, Vassileios Fragoulakis, Evangelia Sarandi et. al. Frontiers in Molecular Biosciences, Metabolomics (6), 2019, Published 1 November 2019.[9] Micronutrient deficiencies in patients with COVID-19: how metabolomics can contribute to their prevention and replenishment. Dimitris Tsoukalas and Evangelia Sarandi. BMJ Nutri Prev Heal. Nov. 2020; bmjnph-2020-000169
[10] Prediction of Autoimmune Diseases by Targeted Metabolomic Assay of Urinary Organic Acids. Dimitris Tsoukalas et. al. Metabolites. 2020 Dec 8.
[11] Metabolic profiling of organic and fatty acids in chronic and autoimmune diseases. Evangelia Sarandi, Dimitris Tsoukalas et al. Advances in Clinical Chemistry. July 15, 2020. Elsevier Inc.
[12] A Clinical Trial for the Identification of Metabolic Biomarkers in Hashimoto’s Thyroiditis and in Psoriasis: Study Protocol by Evangelia Sarandi et al Pathophysiology 2021 https://www.mdpi.com/1873-149X/28/2/19
[13] Non-communicable Diseases in the Era of Precision Medicine: An Overview of the Causing Factors and Prospects. Dimitris Tsoukalas et al. Bio#Futures. Springer, Cham. May 2021.
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